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KMID : 1134819990280061364
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Journal of the Korean Society of Food Science and Nutrition
1999 Volume.28 No. 6 p.1364 ~ p.1368
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Inhibitory Effect of Coprinus comatus Ethanol Extract on the Liver Damage in Benzo(a)pyrene - treated Mice
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Lee Byeung-Hun
Kim Hyun-Jeong
Chang Jong-Sun
Bae Jun-Tae
Park Sun-Hee
Lee Sung-On
Kim Og-Mi
Lee Byul-Ra
Choi Bong-Soon
Lee Kap-Rang
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Abstract
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This study was carried out to investigate the inhibiton effects of Coprinus comatus ethanol extract of edible mushroom on liver damage in benzo(a)pyrene (B(a)P)-treated mice. The activities of serum aminotransferase, cytochrome P-450 and hepatic content of lipid peroxide after B(a)P-treatment were increased than those of control, but those levels were significantly decreased by the treatment of Coprinus comatus ethanol extract. Whereas, the hepatic glutathione content and glutathione S-transferase activity were decreased by B(a)P-treatment than those of control, but those were increased by the treatment of Coprinus comatus ethanol extract. Also the activities of superoxide dismutase, catalase and glutathione peroxidase after B(a)P-treatment were markedly increased than those of control, but those levels were decreased by the treatment of Coprinus comatus ethanol extract. These results suggest that Coprinus comatus ethanol extract have a protective effect on liver damage by benzo(a)pyrene through the mechanisms of decreasing lipid peroxide and activities of free radical generating enzymes.
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KEYWORD
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Coprinus comatus, liver damage, glutathione, glutathione S-transferase
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